Mattle H
Schweiz Med Wochenschr. 1986 Nov 8;116(45):1550-60.
Affections of the vertebral body, the intervertebral disc, the epidural and subdural space, the nerve root, and the spinal cord may have back pain as the main symptom. Initially a topical diagnosis is established in the light of the neurologic symptoms and signs (segmental "beltlike" pain, radicular motor and sensory signs, central mono-, para-, and tetraparesis, as well as sensory signs and bladder dysfunction). Degenerative changes and herniated discs are the most frequent causes of cervical and lumbar spinal disease with neurologic signs, followed by extramedullary tumors. In the extradural space metastases, plasmocytoma, lymphomas and primary bone tumors are the most common, and neurinomas and meningiomas in the intradural space. In the spinal cord ependymomas and astrocytomas are found, as well as benign cavities (syringomyelia). Conditions which are rare, but very important because treatable at an early stage, are spinal epidural hematomas with anticoagulation and spinal epidural abscesses. Vertebral osteomyelitis must also be considered in differential diagnosis. Inflammatory nerve root lesions seldom cause pain, except for subacute demyelinating polyneuropathy responding to corticosteroid treatment, and radiculitis caused by borrelia and herpes zoster.
椎体、椎间盘、硬膜外和硬膜下间隙、神经根及脊髓的病变可能以背痛为主要症状。最初,根据神经症状和体征(节段性“带状”疼痛、神经根性运动和感觉体征、中枢性单瘫、截瘫和四肢瘫,以及感觉体征和膀胱功能障碍)做出局部诊断。退行性改变和椎间盘突出是伴有神经体征的颈腰椎疾病最常见的病因,其次是髓外肿瘤。硬膜外间隙最常见的是转移瘤、浆细胞瘤、淋巴瘤和原发性骨肿瘤,硬膜内间隙是神经鞘瘤和脑膜瘤。脊髓内可发现室管膜瘤和星形细胞瘤,以及良性空洞(脊髓空洞症)。虽然罕见,但因可早期治疗而非常重要的情况是抗凝所致的脊髓硬膜外血肿和脊髓硬膜外脓肿。鉴别诊断时还必须考虑椎体骨髓炎。除了对皮质类固醇治疗有反应的亚急性脱髓鞘性多发性神经病,以及由疏螺旋体和带状疱疹引起的神经根炎外,炎性神经根病变很少引起疼痛。