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跨尺度测量行为。

Measuring behavior across scales.

机构信息

Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, 30322, GA, USA.

出版信息

BMC Biol. 2018 Feb 23;16(1):23. doi: 10.1186/s12915-018-0494-7.

Abstract

The need for high-throughput, precise, and meaningful methods for measuring behavior has been amplified by our recent successes in measuring and manipulating neural circuitry. The largest challenges associated with moving in this direction, however, are not technical but are instead conceptual: what numbers should one put on the movements an animal is performing (or not performing)? In this review, I will describe how theoretical and data analytical ideas are interfacing with recently-developed computational and experimental methodologies to answer these questions across a variety of contexts, length scales, and time scales. I will attempt to highlight commonalities between approaches and areas where further advances are necessary to place behavior on the same quantitative footing as other scientific fields.

摘要

我们最近在测量和操纵神经回路方面取得了成功,这使得对高通量、精确和有意义的行为测量方法的需求得到了放大。然而,朝着这个方向前进的最大挑战不是技术上的,而是概念上的:人们应该给动物正在执行(或不执行)的动作赋予什么样的数值?在这篇综述中,我将描述理论和数据分析的思想是如何与最近开发的计算和实验方法学相连接,以在各种背景、长度和时间尺度下回答这些问题。我将尝试突出方法之间的共同点,以及在哪些方面需要进一步的进展,才能使行为与其他科学领域一样具有定量基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a623/5824583/4a2e695681d4/12915_2018_494_Fig1_HTML.jpg

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