Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark.
J Magn Reson. 2018 Apr;289:92-99. doi: 10.1016/j.jmr.2018.02.011. Epub 2018 Feb 13.
With the translation of metabolic MRI with hyperpolarized C agents into the clinic, imaging approaches will require large volumetric FOVs to support clinical applications. Parallel imaging techniques will be crucial to increasing volumetric scan coverage while minimizing RF requirements and temporal resolution. Calibrationless parallel imaging approaches are well-suited for this application because they eliminate the need to acquire coil profile maps or auto-calibration data. In this work, we explored the utility of a calibrationless parallel imaging method (SAKE) and corresponding sampling strategies to accelerate and undersample hyperpolarized C data using 3D blipped EPI acquisitions and multichannel receive coils, and demonstrated its application in a human study of [1-C]pyruvate metabolism.
随着基于超极化 C 剂的代谢 MRI 进入临床应用，成像方法将需要大的视野 (FOV) 以支持临床应用。并行成像技术对于在最小化 RF 要求和时间分辨率的同时增加容积扫描覆盖范围至关重要。无校准并行成像方法非常适合这种应用，因为它们消除了获取线圈轮廓图或自动校准数据的需要。在这项工作中，我们探索了一种无校准并行成像方法 (SAKE) 的实用性和相应的采样策略，以使用 3D 闪烁 EPI 采集和多通道接收线圈加速和欠采样超极化 C 数据，并在 [1-C]丙酮酸代谢的人体研究中展示了其应用。
