Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China; Laboratory of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China.
Laboratory of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China; Department of Ultrasound, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China; Department of Medical Center, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, China.
Pancreatology. 2018 Apr;18(3):263-268. doi: 10.1016/j.pan.2018.02.004. Epub 2018 Feb 19.
The aim of this study was to investigate the prevalence and risk factors of fatty pancreas in Yangzhou, China.
This was a cross-sectional study. Initially, 2093 subjects were included in the study. After the exclusion of 865 subjects based on incomplete information, a total of 1228 subjects were selected for further analysis. The subjects were stratified into two groups (the fatty pancreas group and the non-fatty pancreas group) based on the results. Anthropometric and biochemical findings were compared between the groups.
Among the 2093 study subjects, 56 (2.7%) had fatty pancreas. Overall, 53 out of 1228 subjects were diagnosed with fatty pancreas and included into the fatty pancreas group. Univariate analysis showed significant differences in age and the prevalence of general obesity, central obesity, alcohol consumption, metabolic syndrome and fatty liver between the two groups (all p < 0.01). The fatty pancreas group had higher levels of aspartate aminotransferase, alanine aminotransferase, serum uric acid, fasting blood glucose, total cholesterol, triglycerides and low-density lipoprotein, and lower levels of high-density lipoprotein than did the non-fatty pancreas group (all p < 0.05). Multivariate logistic regression analysis showed that age (p = 0.007), central obesity (p = 0.002) and fatty liver (p = 0.006) were independent risk factors for fatty pancreas, with odds ratios (ORs) of 1.034 (95% confidence interval (CI): 1.009-1.059), 5.364 (95% CI: 1.890-15.227), and 2.666 (95% CI: 1.332-5.338), respectively.
The prevalence of fatty pancreas in the examined population is approximately 2.7%. Increased age, central obesity and fatty liver disease are independent risk factors for fatty pancreas.
本研究旨在调查中国扬州人群中脂肪性胰腺的患病率及其相关危险因素。
这是一项横断面研究。最初纳入 2093 例受试者，根据信息不完整排除 865 例后，最终共纳入 1228 例受试者进行进一步分析。根据结果将受试者分为两组（脂肪性胰腺组和非脂肪性胰腺组）。比较两组间的人体测量学和生化指标。
在 2093 例研究对象中，56 例（2.7%）患有脂肪性胰腺。总体而言，1228 例受试者中有 53 例被诊断为脂肪性胰腺，纳入脂肪性胰腺组。单因素分析显示两组间年龄及普通肥胖、中心性肥胖、饮酒、代谢综合征和脂肪肝的患病率存在显著差异（均 P < 0.01）。脂肪性胰腺组的天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、血尿酸、空腹血糖、总胆固醇、三酰甘油和低密度脂蛋白水平高于非脂肪性胰腺组，而高密度脂蛋白水平低于非脂肪性胰腺组（均 P < 0.05）。多因素 logistic 回归分析显示，年龄（P = 0.007）、中心性肥胖（P = 0.002）和脂肪肝（P = 0.006）是脂肪性胰腺的独立危险因素，其优势比（OR）分别为 1.034（95%置信区间（CI）：1.009-1.059）、5.364（95% CI：1.890-15.227）和 2.666（95% CI：1.332-5.338）。
所调查人群中脂肪性胰腺的患病率约为 2.7%。年龄增长、中心性肥胖和脂肪肝是脂肪性胰腺的独立危险因素。
