Savage D D, Garrison R J, Kannel W B, Levy D, Anderson S J, Stokes J, Feinleib M, Castelli W P
Circulation. 1987 Jan;75(1 Pt 2):I26-33.
To assess the prevalence, characteristics, and correlates of echocardiographically determined left ventricular hypertrophy (echo LVH) in a free-living population, 510 men and 855 women from the original Framingham cohort (age 59 to 90 years) were studied by M-mode echocardiography. Offspring and offspring spouses (1718 men and 1892 women; age 17 to 75 years) were similarly studied. The severity of echo LVH, as reflected by left ventricular mass indexed to body surface area, ranged from 101 g/m2 (women) and 132 g/m2 (men) to more than 400 g/m2. The prevalence of electrocardiographically assessed LVH increased proportionately with increased echocardiographic left ventricular mass. Women with echocardiographic left ventricular mass indexes exceeding 200 g/m2 were three to four times more likely to have electrocardiographic LVH than men with similar elevations of echocardiographic left ventricular mass index. The prevalence of echo LVH ranged from 6.6% in the younger (offspring study) women to 33% in the older (original cohort) women (8.6% and 23.7%, respectively, for men) and included a spectrum of forms--eccentric-dilated, eccentric-nondilated, concentric, and disproportionate septal thickness--which varied in prevalence in the various age-sex groups. Each of these forms of echo LVH was associated with higher systolic blood pressures at the time of echocardiographic examination and over the previous 30 years when compared with blood pressures of Framingham subjects without echo LVH.
为评估自由生活人群中经超声心动图测定的左心室肥厚（超声心动图左心室肥厚）的患病率、特征及相关因素，对来自原弗雷明汉队列（年龄59至90岁）的510名男性和855名女性进行了M型超声心动图研究。对后代及后代配偶（1718名男性和1892名女性；年龄17至75岁）进行了类似研究。以体表面积指数化的左心室质量所反映的超声心动图左心室肥厚严重程度，范围从101 g/m²（女性）和132 g/m²（男性）至超过400 g/m²。经心电图评估的左心室肥厚患病率随超声心动图左心室质量增加而呈比例上升。超声心动图左心室质量指数超过200 g/m²的女性发生心电图左心室肥厚的可能性是超声心动图左心室质量指数有类似升高的男性的三至四倍。超声心动图左心室肥厚的患病率从较年轻（后代研究）女性中的6.6%至较年长（原队列）女性中的33%不等（男性分别为8.6%和23.7%），且包括一系列类型——离心性扩张型、离心性非扩张型、向心性和不成比例的室间隔增厚型——在不同年龄 - 性别组中患病率各异。与无超声心动图左心室肥厚的弗雷明汉研究对象的血压相比，这些超声心动图左心室肥厚类型中的每一种在超声心动图检查时及此前30年中均与较高的收缩压相关。
