MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4 Rue Larrey, F-49933 Angers, France.
MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4 Rue Larrey, F-49933 Angers, France.
Eur J Pharmacol. 2018 Apr 15;825:92-98. doi: 10.1016/j.ejphar.2018.02.033. Epub 2018 Feb 22.
N,N-diethyl-m-toluamide (DEET) induces favorable repellency against insects by acting on the sensory nervous system. According to emerging literature reports, DEET side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (AChE), muscarinic M1 and M3 receptor and the participation of the second messenger nitric oxide (NO). Most of these molecular events targeted by DEET have previously been characterized in insects while they have been considered as marginal compared to classical repellent properties. Despite these uncommon actions in insects, there is no consensus on the effects in human. Based on these data, this review provides new insights on side effects in human and more largely in mammals by identifying the unusual properties of DEET in insects, which seem to be correlated with adverse effects in mammals. These data will be very helpful to understand better the toxicological effects observed in order to protect non-target organisms from the toxicity.
N,N-二乙基间甲苯甲酰胺（DEET）通过作用于感觉神经系统对昆虫产生有利的驱避作用。根据新兴的文献报道，DEET 在人类中的副作用涉及新的分子靶标，包括胆碱能系统、乙酰胆碱酯酶（AChE）、毒蕈碱 M1 和 M3 受体以及第二信使一氧化氮（NO）的参与。DEET 靶向的这些大多数分子事件以前在昆虫中得到了表征，而与经典的驱避特性相比，这些事件被认为是次要的。尽管昆虫中存在这些不常见的作用，但人类的作用尚无共识。基于这些数据，本综述通过鉴定 DEET 在昆虫中的异常特性，为人类和更广泛的哺乳动物中的副作用提供了新的见解，这些特性似乎与哺乳动物的不良影响相关。这些数据将非常有助于更好地理解观察到的毒理学效应，以保护非靶标生物免受毒性影响。
