从黄芩中提取芹菜素的绿色工艺的开发和表征。
Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don.
机构信息
Department and Graduate Institute of Pharmacology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Department of Applied Geoinformatics, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.
出版信息
Food Chem. 2018 Jun 30;252:381-389. doi: 10.1016/j.foodchem.2017.12.086. Epub 2017 Dec 28.
This study compared the use of ultrasound-assisted supercritical CO (USC-CO) extraction to obtain apigenin-rich extracts from Scutellaria barbata D. Don with that of conventional supercritical CO (SC-CO) extraction and heat-reflux extraction (HRE), conducted in parallel. This green procedure yielded 20.1% and 31.6% more apigenin than conventional SC-CO extraction and HRE, respectively. Moreover, the extraction time required by the USC-CO procedure, which used milder conditions, was approximately 1.9 times and 2.4 times shorter than that required by conventional SC-CO extraction and HRE, respectively. Furthermore, the theoretical solubility of apigenin in the supercritical fluid system was obtained from the USC-CO dynamic extraction curves and was in good agreement with the calculated values for the three empirical density-based models. The second-order kinetics model was further applied to evaluate the kinetics of USC-CO extraction. The results demonstrated that the selected model allowed the evaluation of the extraction rate and extent of USC-CO extraction.
本研究比较了超声辅助超临界 CO（USC-CO）提取与常规超临界 CO（SC-CO）提取和热回流提取（HRE）从 Scutellaria barbata D. Don 中获得富含芹菜素的提取物的方法。与常规 SC-CO 提取和 HRE 相比，这种绿色工艺分别获得了 20.1%和 31.6%更多的芹菜素。此外，USC-CO 工艺使用的条件较为温和，所需的提取时间分别比常规 SC-CO 提取和 HRE 缩短了约 1.9 倍和 2.4 倍。此外，从 USC-CO 动态提取曲线获得了芹菜素在超临界流体系统中的理论溶解度，并与三个基于密度的经验模型的计算值吻合良好。进一步应用二阶动力学模型来评估 USC-CO 提取的动力学。结果表明，所选模型允许评估 USC-CO 提取的提取速率和程度。
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