韩国女性中 、 、 、因子 1 微生物的高流行率与自然流产的相关性。
High Prevalence of , , , and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women.
机构信息
Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea.
Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
出版信息
Biomed Res Int. 2017;2017:5435089. doi: 10.1155/2017/5435089. Epub 2017 Dec 13.
The purpose of this study was to (i) determine the cervical microbial composition in different abortion samples and to (ii) investigate the correlation between spontaneous abortion and cervical microbes in Korean women. We collected cervical swabs from women who had never undergone abortion ( = 36), had spontaneous abortion ( = 23), and had undergone induced abortion ( = 88) and subjected those samples to 16S rRNA pyrosequencing. Further, factor analysis and correlation between cervical microbiota and spontaneous abortion were evaluated by logistic regression analysis. In spontaneous abortion women, 16 S rRNA gene sequences showed significant increases in , spp., , , and compared to women in nonabortion group. In multivariate logistic regression analysis, (OD = 11.27; 95% = 1.57-81) (OD = 11.47; 95% = 1.22-107.94), (OD = 6.89; 95% = 1.07-44.33), and factor 1 microbes (OD = 16.4; 95% = 1.88-42.5) were strongly associated with spontaneous abortion. This study showed a high prevalence of , and factor 1 microbes in spontaneous abortion and association with spontaneous abortion in Korean women.
本研究旨在
（i）确定不同流产样本中的宫颈微生物组成；（ii）研究韩国女性自然流产与宫颈微生物之间的相关性。我们收集了从未经历过流产（=36 例）、自然流产（=23 例）和人工流产（=88 例）的女性的宫颈拭子，并对这些样本进行了 16S rRNA 焦磷酸测序。此外，通过逻辑回归分析评估了宫颈微生物群与自然流产之间的因子分析和相关性。在自然流产妇女中，与非流产组相比，16S rRNA 基因序列中 、 、 、 、 和 显著增加。在多变量逻辑回归分析中， （OD=11.27；95%=1.57-81）（OD=11.47；95%=1.22-107.94）、 （OD=6.89；95%=1.07-44.33）和因子 1 微生物（OD=16.4；95%=1.88-42.5）与自然流产密切相关。本研究表明，在韩国女性中，自然流产中存在高比例的 和因子 1 微生物，并且与自然流产相关。
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