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分娩方式和母体因素对新生儿口腔微生物群的影响。

Impacts of Delivery Mode and Maternal Factors on Neonatal Oral Microbiota.

作者信息

Xu Tiansong, Yan Lihuang, Sun Bohui, Xu Qi, Zhang Jieni, Zhu Wenhui, Zhang Qian, Chen Ning, Liu Guoli, Chen Feng

机构信息

Central Laboratory, Peking University School of Stomatology, Beijing, China.

Department of Obstetrics, Peking University People's Hospital, Beijing, China.

出版信息

Front Microbiol. 2022 Jun 27;13:915423. doi: 10.3389/fmicb.2022.915423. eCollection 2022.

DOI:10.3389/fmicb.2022.915423
PMID:35832807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9271910/
Abstract

OBJECTIVES

Initial oral microbial colonization has complicatedly interacted with growth and development. The aim of our study was to discover links between oral microbiota community structure and mode of delivery, maternal factors, such as systemic diseases, abortion history, and pregnancy complications.

METHODS

A total of 177 pregnant women and their neonates were enrolled at Peking university people's hospital. We collected oral samples, medical history, and development phenotype and used a 16S rRNA gene sequence to analyze microbial diversity at all taxonomic levels, network structure, and metabolic characteristics.

RESULTS

, , and were the most predominant bacteria of neonatal oral samples among these phyla. Alpha-diversity of pregnant women with gestational diabetes mellitus (GDM), abortion history, and without immune diseases was higher than in control groups, and no significant dissimilarity in beta-diversity was observed between different maternal factors. Obvious separation or trend failed to be seen in different development phenotype groups. Besides, were significantly more abundant in a natural delivery group than in the cesarean section group.

CONCLUSION

Our study indicated that maternal factors and mode of delivery influenced the oral microbial structure, but longitudinal studies were indispensable for capturing the long-term effects on neonatal development phenotype and oral microbiota.

摘要

目的

口腔微生物的初始定植与生长发育存在复杂的相互作用。我们研究的目的是发现口腔微生物群落结构与分娩方式、母亲因素（如全身性疾病、流产史和妊娠并发症）之间的联系。

方法

北京大学人民医院招募了177名孕妇及其新生儿。我们收集了口腔样本、病史和发育表型，并使用16S rRNA基因序列分析了所有分类水平上的微生物多样性、网络结构和代谢特征。

结果

在这些门中， 、 和 是新生儿口腔样本中最主要的细菌。患有妊娠期糖尿病（GDM）、有流产史且无免疫疾病的孕妇的α多样性高于对照组，不同母亲因素之间在β多样性上未观察到显著差异。在不同发育表型组中未观察到明显的分离或趋势。此外，自然分娩组中的 明显比剖宫产组更为丰富。

结论

我们的研究表明，母亲因素和分娩方式会影响口腔微生物结构，但纵向研究对于了解对新生儿发育表型和口腔微生物群的长期影响是必不可少的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/546a9cb76b1d/fmicb-13-915423-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/741f85a62e6e/fmicb-13-915423-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/9615a1955dc1/fmicb-13-915423-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/d25ae5a9f9a4/fmicb-13-915423-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/786cb6b47a23/fmicb-13-915423-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/ade03cc9e731/fmicb-13-915423-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/546a9cb76b1d/fmicb-13-915423-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/741f85a62e6e/fmicb-13-915423-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/9615a1955dc1/fmicb-13-915423-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/d25ae5a9f9a4/fmicb-13-915423-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/786cb6b47a23/fmicb-13-915423-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/ade03cc9e731/fmicb-13-915423-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca9b/9271910/546a9cb76b1d/fmicb-13-915423-g006.jpg

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The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention.妊娠期糖尿病的肠道微生物特征及其与饮食干预的关联。
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