NADPH 代谢：在氨基酸生物合成中对其理论特性和操纵策略的调查。
NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis.
机构信息
a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , WuXi , PR China.
b The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , WuXi , PR China.
出版信息
Crit Rev Biotechnol. 2018 Nov;38(7):1061-1076. doi: 10.1080/07388551.2018.1437387. Epub 2018 Feb 25.
Reduced nicotinamide adenine nucleotide phosphate (NADPH), which is one of the key cofactors in the metabolic network, plays an important role in the biochemical reactions, and physiological function of amino acid-producing strains. The manipulation of NADPH availability and form is an efficient and easy method of redirecting the carbon flux to the amino acid biosynthesis in industrial strains. In this review, we survey the metabolic mode of NADPH. Furthermore, we summarize the research developments in the understanding of the relationship between NADPH metabolism and amino acid biosynthesis. Detailed strategies to manipulate NADPH availability are addressed based on this knowledge. Finally, the uses of NADPH manipulation strategies to enhance the metabolic function of amino acid-producing strains are discussed.
还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）是代谢网络中的关键辅酶之一，在氨基酸产生菌的生化反应和生理功能中发挥着重要作用。NADPH 的可用性和形式的操纵是一种有效且简便的方法，可以将碳通量重新导向工业菌株中的氨基酸生物合成。在这篇综述中，我们调查了 NADPH 的代谢模式。此外，我们总结了在理解 NADPH 代谢与氨基酸生物合成之间关系方面的研究进展。基于这些知识，我们提出了详细的操纵 NADPH 可用性的策略。最后，讨论了 NADPH 操纵策略在增强氨基酸产生菌的代谢功能方面的应用。
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