Yang Jai-Sing, Peng Yan-Ru, Tsai Shih-Chang, Tyan Yeu-Sheng, Lu Chi-Cheng, Chiu Hong-Yi, Chiu Yu-Jen, Kuo Sheng-Chu, Tsai Yuh-Feng, Lin Ping-Chin, Tsai Fuu-Jen
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
School of Medicine, China Medical University, Taichung 404, Taiwan.
Biomedicine (Taipei). 2018 Mar;8(1):1. doi: 10.1051/bmdcn/2018080101. Epub 2018 Feb 26.
Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM.
碘化造影剂（碘造影剂）吸收X射线的能力增强，能够使在放射检查中通常无法观察到的结构显影。使用碘造影剂可能会损害肾功能，即通常所说的造影剂肾病（CIN），这可能导致急性肾衰竭（ARF）。这篇综述文章主要关注以下几个方面：（1）碘造影剂的分类：离子型或非离子型、高渗性造影剂（HOCM）、低渗性造影剂（LOCM）和等渗性造影剂（IOCM）；（2）非离子型碘造影剂的物理和化学性质介绍；（3）碘造影剂过敏反应的处理；（4）非离子型碘造影剂成人单次注射剂量及最大剂量建议；（5）造影剂肾病（CIN）的分子机制；（6）碘造影剂的体外研究。基于上述信息，这篇综述文章为理解碘造影剂的药物安全性提供了见解。
