Product Development Cell - II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India.
Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), Jammu Campus, Jammu 180001, India.
Drug Discov Today. 2018 May;23(5):1115-1125. doi: 10.1016/j.drudis.2018.02.005. Epub 2018 Feb 23.
In recent years, research has focused on the development of smart nanocarriers that can respond to specific stimuli. Among the various stimuli-responsive platforms for cancer therapy, near-infrared (NIR) light (700-1000nm)-responsive nanocarriers have gained considerable interest because of their deeper tissue penetration capacity, precisely controlled drug release, and minimal damage towards normal tissues. In this review, we outline various therapeutic applications of NIR-responsive nanocarriers in drug delivery, photothermal therapy (PTT), photodynamic therapy (PDT), and bioimaging. We also highlight recent trends towards NIR-responsive combinatorial therapy and multistimuli-responsive nanocarriers for improving therapeutic outcomes.
近年来，研究集中在开发能够对特定刺激做出响应的智能纳米载体上。在用于癌症治疗的各种刺激响应平台中，近红外（NIR）光（700-1000nm）响应纳米载体由于其更深的组织穿透能力、精确控制药物释放以及对正常组织的最小损伤而引起了相当大的兴趣。在这篇综述中，我们概述了 NIR 响应纳米载体在药物输送、光热治疗（PTT）、光动力治疗（PDT）和生物成像中的各种治疗应用。我们还强调了 NIR 响应组合治疗和多刺激响应纳米载体的最新趋势，以改善治疗效果。
