Institutes for Life Sciences, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510006, China.
Curr Med Chem. 2020;27(23):3877-3887. doi: 10.2174/0929867326666190215113522.
Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.
用于按需药物递送的红光和近红外光响应型聚合物纳米载体因其在癌症治疗方面的巨大潜力而受到广泛关注。已经应用了各种策略来制备这种纳米载体，并且它们已经显示出对正常组织的显著治疗效果和最小的毒性。在这里，我们将回顾各种红光和近红外光响应型聚合物纳米载体在按需药物递送方面的最新进展，包括促进药物内化和在靶向部位增强药物释放。我们总结了它们的组成和设计策略，并强调了光活化变体增强药物摄取和药物释放的机制。我们试图为按需药物递送的红光和近红外光响应型聚合物纳米载体的制备提供新的见解。
