Bae Woong Jin, Choi Jin Bong, Moon Hyong Woo, Park Young Hyun, Cho Hyuk Jin, Hong Sung-Hoo, Lee Ji Youl, Kim Sae Woong, Han Kyung-Do, Ha U-Syn
Department of Urology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
Cancer Research Institute, the Catholic University of Korea, Seoul, Republic of Korea.
J Cancer. 2018 Jan 1;9(3):488-493. doi: 10.7150/jca.22107. eCollection 2018.
To examine the association between obesity and urothelial cancer, we used a representative data from the National Health Insurance System (NHIS). Participants included 826,170 men aged 20 years and older who experienced a health examination at least one time between 2004 and 2008. The study thus excluded people aged <20 years and women. We used a multivariate adjusted Cox regression analysis to examine the association between urothelial cancer and body mass index (BMI) via a hazard ratio (HR) and 95% confidence interval (CI). The age- or multivariable-adjusted HR for urothelial cancer was stratified by BMI. Men with a higher BMI were more likely to acquire urothelial cancer independent of variables. In the population with diabetes, there showed a considerable, increasing trend in the risk of urothelial cancer in the overweight and obesity group, compared to the group with the same BMI but without diabetes. This population-based study showed evidence of an association between obesity and the development of urothelial cancer, where the presence of diabetes increased the risk of urothelial cancer. Additionally, the higher the BMI, the higher the risk for urothelial cancer.
为研究肥胖与尿路上皮癌之间的关联，我们使用了来自国民健康保险系统（NHIS）的代表性数据。研究对象包括826,170名年龄在20岁及以上的男性，他们在2004年至2008年期间至少接受过一次健康检查。因此，该研究排除了年龄小于20岁的人群和女性。我们使用多变量调整的Cox回归分析，通过风险比（HR）和95%置信区间（CI）来研究尿路上皮癌与体重指数（BMI）之间的关联。尿路上皮癌的年龄调整或多变量调整HR按BMI进行分层。BMI较高的男性更有可能独立于其他变量患上尿路上皮癌。在糖尿病患者群体中，与BMI相同但无糖尿病的群体相比，超重和肥胖组的尿路上皮癌风险呈现出相当大的上升趋势。这项基于人群的研究表明，肥胖与尿路上皮癌的发生之间存在关联，其中糖尿病的存在增加了尿路上皮癌的风险。此外，BMI越高，患尿路上皮癌的风险越高。
