So Young Moon, MD, PhD, Department of Neurology, School of Medicine, Ajou University, 5 San, Woncheon-dong, Yongtong-gu, Suwon-si, Kyunggi-do, 442-749, Republic of Korea, Tel: +82-31-219-5175, Fax: +82-31-219-5178, E-mail:
J Nutr Health Aging. 2018;22(3):425-430. doi: 10.1007/s12603-017-0959-3.
Since physical activity (PA) has demonstrated benefits for cardiovascular health, it is possible to hypothesize that higher or increasing PA slows the progression of white matter hyperintensities (WMH). We investigated the association between PA and the progression of WMH in non-demented older adults with memory complaints.
We included 152 participants (mean age 74.7±3.8 years; 63.8% women) in the analyses, in whom information on self-reported PA and MRI was available at both baseline and 3-year follow-up. From the PA questionnaire, the baseline metabolic equivalent of task (MET-minute/week) and changes in MET-minute/week over three years were separately calculated for overall, leisure-time, and non-leisure time PA. WMH volume at baseline and 3-year follow-up was obtained by using an automated segmentation algorithm.
Mixed-effect linear regression models showed that none of the baseline PA variables was associated with progression of WMH over time. People who had decreased their PA levels over three years tended to show greater progression of WMH compared with those who had maintained PA levels of ≥1200 MET-min/week (roughly equivalent to ≥300 minutes of brisk walking) in the unadjusted model (β±SE=4.85±2.42, p=0.045); however, this association was no longer significant after adjustment for confounders (β±SE =3.63±2.18, p=0.096).
We did not find any significant association between PA and WMH in non-demented older adults with memory complaints. However, decrease over time in PA levels tended to be associated with progression of WMH. A larger longitudinal study with data on PA assessed using objective measures would provide important information in this field.
由于身体活动（PA）已显示出对心血管健康的益处，因此可以假设更高或增加的 PA 会减缓脑白质高信号（WMH）的进展。我们调查了有记忆主诉的非痴呆老年人群中 PA 与 WMH 进展之间的关系。
我们将 152 名参与者（平均年龄 74.7±3.8 岁，63.8%为女性）纳入分析，他们在基线和 3 年随访时均提供了关于自我报告的 PA 和 MRI 的信息。从 PA 问卷中，分别计算了基线代谢当量任务（MET-分钟/周）和三年间 MET-分钟/周的变化，用于整体、休闲时间和非休闲时间的 PA。基线和 3 年随访时的 WMH 体积是通过使用自动分割算法获得的。
混合效应线性回归模型显示，PA 的基线变量均与 WMH 的随时间进展无关。与那些保持 PA 水平≥1200 MET-min/周（大致相当于≥300 分钟快走）的人相比，三年间 PA 水平下降的人，其 WMH 进展程度更大（未调整模型中的β±SE=4.85±2.42，p=0.045）；然而，在调整混杂因素后，这种关联不再显著（β±SE=3.63±2.18，p=0.096）。
我们在有记忆主诉的非痴呆老年人群中未发现 PA 与 WMH 之间存在任何显著关联。然而，PA 水平随时间的下降趋势与 WMH 的进展有关。一项更大的纵向研究，使用客观测量评估 PA 数据，将为这一领域提供重要信息。
