a Department of Medical Biotechnology , Yeungnam University , Gyeongsan , South Korea.
b Department of Biochemistry and Molecular Biology, Smart-Aging Convergence Research Center , Yeungnam University College of Medicine , Daegu , South Korea.
Clin Exp Hypertens. 2019;41(1):20-27. doi: 10.1080/10641963.2018.1441856. Epub 2018 Feb 27.
Central blood pressure is closely related to the important cardiovascular intermediate end points, such as vascular hypertrophy and extent of carotid atherosclerosis. Therefore it is prudent to study correlation among central aortic blood pressure, body composition, lipid profiles, and pulse wave velocity in population-based study. Consequently, we investigate the correlation between central aortic blood pressure and other risk parameters of hypertension such as body composition and lipid profile.
We recruited 20 young participants diagnosed with hypertension as well as 30 without hypertension. The study used an X-SCAN PLUS 950 machine for measurement of overall body composition. Measurements of central blood pressure and carotid-femoral pulse wave velocity were carried out using SphygmoCor XCEL.
The hypertensive participants had significantly higher total weight without fat, body moisture mass, muscle mass, body mass index, basal metabolic rate, intracellular and extracellular water contents, protein and mineral contents along with brachial and central aortic blood pressures. In both hypertensive and non-hypertensive participants, central aortic diastolic blood pressure were significantly related to the lipid parameters.
Overall, the correlations between central blood pressure, pulse wave velocity, and lipid profile in hypertensive and non-hypertensive participants were substantial.
中心血压与重要的心血管中间终点密切相关，如血管肥大和颈动脉粥样硬化程度。因此，在基于人群的研究中，研究中心主动脉血压、身体成分、血脂谱和脉搏波速度之间的相关性是谨慎的。因此，我们研究了中心主动脉血压与高血压的其他风险参数（如身体成分和血脂谱）之间的相关性。
我们招募了 20 名被诊断为高血压的年轻参与者和 30 名没有高血压的参与者。该研究使用 X-SCAN PLUS 950 机器测量全身身体成分。使用 SphygmoCor XCEL 测量中心血压和颈动脉-股动脉脉搏波速度。
高血压组的总无脂体重、体水分质量、肌肉质量、体重指数、基础代谢率、细胞内和细胞外水分含量、蛋白质和矿物质含量以及肱动脉和中心主动脉血压均显著升高。在高血压和非高血压组参与者中，中心主动脉舒张压与血脂参数显著相关。
总之，高血压和非高血压组参与者的中心血压、脉搏波速度和血脂谱之间存在显著相关性。
