Department of Endocrinology and Metabolism, Nagasaki University Hospital, Nagasaki, Japan.
J Diabetes Investig. 2018 Nov;9(6):1283-1287. doi: 10.1111/jdi.12829. Epub 2018 Mar 30.
It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22-30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme-linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi-hormonal responses in healthy individuals.
据报道，健康女性和男性在口服葡萄糖耐量试验期间的葡萄糖反应不同。然而，目前尚不清楚是什么因素导致了两性之间的这些差异。本研究分析了 25 名健康年轻女性和 38 名健康年轻男性（年龄 22-30 岁）在口服葡萄糖耐量试验期间的胰岛素和胰高血糖素反应。女性 120 分钟时的血浆葡萄糖水平明显高于男性。女性在 30、90 和 120 分钟时的胰岛素分泌明显高于男性。用夹心酶联免疫吸附试验胰高血糖素试剂盒测定时，男性在 30 和 120 分钟时的胰高血糖素抑制作用明显大于女性。这些结果表明，口服葡萄糖耐量试验期间葡萄糖反应的差异是由健康个体中两性双激素反应的差异介导的。
