Chen Guopu, Ren Jianan, Deng Youming, Wu Xiuwen, Huang Jinjian, Wang Gefei, Zhao Yuanjin, Li Jieshou
J Biomed Nanotechnol. 2017 Dec 1;13(12):1660-1672. doi: 10.1166/jbn.2017.2443.
Rapid wound healing is a fundamental health concern and poses a critical challenge for healthcare systems worldwide. Here, we developed an injectable, dynamic, self-healing hydrogel serving as a fibroblast growth factor 2 (FGF2) delivery system for tissue repair applications. Benzaldehyde-terminated polyethylene glycol (BAPEG) was synthesized and cross-linked with N-Succinyl-chitosan (SCS) through reversible Schiff-base reaction to form a dynamic self-healing hydrogel. Because it can be injected after gelation and self-heal into an integral part, the hydrogel could not only auto-adapt to the irregular wound surface to provide better protection but also encapsulate drugs homogeneously and implant into tissue with a less invasive strategy. As a result, the FGF2-loaded SCS/BAPEG hydrogel is able to significantly promote the process of angiogenesis, collagen deposition, and granulation tissue formation, as well as reduce inflammation. This study opens the door to self-healing hydrogels serving as a drug delivery system for tissue repair applications.
快速伤口愈合是一项基本的健康问题，对全球医疗系统构成了严峻挑战。在此，我们开发了一种可注射、动态、自愈合水凝胶，作为用于组织修复应用的成纤维细胞生长因子2（FGF2）递送系统。合成了苯甲醛封端的聚乙二醇（BAPEG），并通过可逆席夫碱反应与N-琥珀酰壳聚糖（SCS）交联，形成动态自愈合水凝胶。由于该水凝胶在凝胶化后可以注射并自愈合为一个整体部分，它不仅可以自动适应不规则的伤口表面以提供更好的保护，还能均匀地包裹药物，并以侵入性较小的策略植入组织。因此，负载FGF2的SCS/BAPEG水凝胶能够显著促进血管生成、胶原蛋白沉积和肉芽组织形成过程，并减轻炎症。这项研究为自愈合水凝胶作为用于组织修复应用的药物递送系统打开了大门。
