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头皮原发性I型皮肤脑膜瘤:一种罕见肿瘤的细胞组织学和免疫组化特征

Primary Type I Cutaneous Meningioma of the Scalp: Cytohistological and Immunohistochemical Features of a Rare Neoplasm.

作者信息

Jaiswal Pooja, Jaiswal Somil, Chakrabarti Sudipta, Mukherjee Anumoy

机构信息

Department of Pathology, ESI PGIMSR, Manicktala, Kolkata, West Bengal, India.

Department of Neurosurgery, King George's Medical University, Lucknow, Uttar Pradesh, India.

出版信息

Asian J Neurosurg. 2018 Jan-Mar;13(1):110-112. doi: 10.4103/1793-5482.181123.

Abstract

Primary cutaneous meningioma of scalp is a rare lesion and often clinically misdiagnosed. As clinical features are nonspecific, the diagnosis is often perplexing in this exceptional site. We report a case of a 7-year-old girl presenting with a nodule over occipital region of scalp since birth. No bony defect was noted on X-ray. On fine needle aspiration cytology, smears were cellular consisting mostly cohesive clusters of cells having pale pink granular cytoplasm, round to oval nuclei with unassuming nucleoli along with psammomatous calcification suggestive of cutaneous meningioma. Histology and immunohistochemistry with epithelial membrane antigen (EMA) confirmed the diagnosis. Histological sections revealed a proliferation of a spindle-shaped cell in the dermis, arranged in whorls or individually amid collagen fibers and psammoma bodies. Immunohistochemical study revealed positivity for EMA. A diagnosis of Type I cutaneous meningioma was finally rendered based on characteristic clinical, intraoperative, morphological, and immunohistochemical observations.

摘要

头皮原发性脑膜瘤是一种罕见的病变,临床上常被误诊。由于临床特征不具有特异性,在这个特殊部位的诊断往往令人困惑。我们报告一例7岁女孩,自出生以来枕部头皮出现一个结节。X线检查未发现骨缺损。细针穿刺细胞学检查显示涂片细胞丰富,主要为细胞黏附性聚集,细胞具有淡粉色颗粒状细胞质、圆形至椭圆形细胞核以及不明显的核仁,伴有砂粒体钙化,提示为皮肤脑膜瘤。组织学检查及上皮膜抗原(EMA)免疫组化检查确诊。组织学切片显示真皮内梭形细胞增生,呈漩涡状排列或单个散在于胶原纤维和砂粒体之间。免疫组化研究显示EMA呈阳性。最终根据特征性的临床、术中、形态学及免疫组化表现诊断为I型皮肤脑膜瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37be/5820862/4528551dde6b/AJNS-13-110-g001.jpg

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