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同型半胱氨酸水平与钙化性主动脉瓣疾病之间的关联：一项系统评价与荟萃分析。

Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis.

作者信息

Wu Guandi, Xian Jiayi, Yang Xi, Li Jiaying, Liu Jichen, Dong Wenhui, Su Shuwen, Li Jun, Tu Yan, Peng Jian, Xu Dingli, Zeng Qingchun

机构信息

Department of Cardiology, First Clinical Medical College, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China.

出版信息

Oncotarget. 2018 Jan 3;9(9):8665-8674. doi: 10.18632/oncotarget.23938. eCollection 2018 Feb 2.

DOI:10.18632/oncotarget.23938
PMID:29492225
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5823577/
Abstract

Previous studies have reported inconsistent results regarding the association between homocysteine (Hcy) levels and calcific aortic valve disease (CAVD). We investigate the association between Hcy levels in patients with CAVD and controls by conducting a systematic review and meta-analysis. We conducted a systematic search of studies published prior to the end of March 2017 in the PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and the Chinese Biomedical Literature databases. Eligible studies evaluating plasma Hcy levels in CAVD patients and controls were identified by two independent investigators. Standardized mean difference (SMD) and the corresponding 95% confidence intervals (95% CIs) were estimated using the random-effects model. Ten studies involving 6349 participants were included. Pooled analysis demonstrated that Hcy levels were significantly elevated in patients with CAVD compared with controls (pooled SMD: 0.57, 95% CI: 0.36-0.79). This elevation was more obvious in American and Asian populations than in Turkish populations. Furthermore, Hcy levels were significantly elevated in patients with mild-to-moderate CAVD and severe CAVD. Our results demonstrate that CAVD is associated with elevated Hcy levels.

摘要

以往的研究报告了同型半胱氨酸（Hcy）水平与钙化性主动脉瓣疾病（CAVD）之间的关联存在不一致的结果。我们通过进行系统评价和荟萃分析，研究CAVD患者与对照组中Hcy水平之间的关联。我们对截至2017年3月底发表在PubMed、Embase、科学网、Cochrane对照试验中心注册库和中国生物医学文献数据库中的研究进行了系统检索。由两名独立研究人员确定评估CAVD患者和对照组血浆Hcy水平的合格研究。使用随机效应模型估计标准化均数差（SMD）和相应的95%置信区间（95%CI）。纳入了10项涉及6349名参与者的研究。汇总分析表明，与对照组相比，CAVD患者的Hcy水平显著升高（汇总SMD：0.57，95%CI：0.36 - 0.79）。这种升高在美国和亚洲人群中比在土耳其人群中更明显。此外，轻度至中度CAVD患者和重度CAVD患者的Hcy水平均显著升高。我们的结果表明，CAVD与Hcy水平升高有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/4d1a97d408ea/oncotarget-09-8665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/094ddf5e90a0/oncotarget-09-8665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/c7b1e47fccb7/oncotarget-09-8665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/db2a09a5ee9b/oncotarget-09-8665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/e13c14cd57bf/oncotarget-09-8665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/5656523c1c7a/oncotarget-09-8665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/4d1a97d408ea/oncotarget-09-8665-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/094ddf5e90a0/oncotarget-09-8665-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/c7b1e47fccb7/oncotarget-09-8665-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/db2a09a5ee9b/oncotarget-09-8665-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/e13c14cd57bf/oncotarget-09-8665-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/5656523c1c7a/oncotarget-09-8665-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b38/5823577/4d1a97d408ea/oncotarget-09-8665-g006.jpg

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引用本文的文献

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Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification.

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Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers.

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[6]
Optimal antithrombotic therapy after transcatheter aortic valve replacement in patients with atrial fibrillation.

Ther Adv Chronic Dis. 2020-10-14

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