Patze Sophie, Huebner Uwe, Weber Karina, Cialla-May Dana, Popp Juergen
Leibniz Institute of Photonic Technology e. V. (IPHT), Albert-Einstein-Str. 9, 07745 Jena, Germany.
Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller-University Jena, Helmholtzweg 4, 07743 Jena, Germany.
Materials (Basel). 2018 Feb 24;11(2):325. doi: 10.3390/ma11020325.
Surface-enhanced Raman spectroscopy (SERS) is known as a molecular-specific and highly sensitive method. In order to enable the routine application of SERS, powerful SERS substrates are of great importance. Within this manuscript, a TopUp SERS substrate is introduced which is fabricated by a top-down process based on microstructuring as well as a bottom-up generation of silver nanostructures. The Raman signal of the support material acts as an internal standard in order to improve the quantification capabilities. The analyte molecule coverage of sulfamethoxazole on the surface of the nanostructures is characterized by the SERS signal evolution fitted by a Langmuir-Freundlich isotherm.
表面增强拉曼光谱（SERS）是一种分子特异性且高度灵敏的方法。为了使SERS能够常规应用，强大的SERS基底至关重要。在本论文中，介绍了一种TopUp SERS基底，它是通过基于微结构化的自上而下工艺以及银纳米结构的自下而上生成来制造的。支撑材料的拉曼信号用作内标以提高定量能力。纳米结构表面上磺胺甲恶唑的分析物分子覆盖情况通过由朗缪尔 - 弗伦德利希等温线拟合的SERS信号演变来表征。
