Department of Speech, Language, and Hearing Sciences, Western Michigan University, Kalamazoo.
Am J Speech Lang Pathol. 2018 Mar 1;27(1S):291-305. doi: 10.1044/2018_AJSLP-16-0180.
The number of research articles aimed at identifying neuroimaging biomarkers for predicting recovery from aphasia continues to grow. Although the clinical use of these biomarkers to determine prognosis has been proposed, there has been little discussion of how this would be accomplished. This is an important issue because the best translational science occurs when translation is considered early in the research process. The purpose of this clinical focus article is to present a framework to guide the discussion of how neuroimaging biomarkers for recovery from aphasia could be implemented clinically.
The genomics literature reveals that implementing genetic testing in the real-world poses both opportunities and challenges. There is much similarity between these opportunities and challenges and those related to implementing neuroimaging testing to predict recovery in aphasia. Therefore, the Center for Disease Control's model list of questions aimed at guiding the review of genetic testing has been adapted to guide the discussion of using neuroimaging biomarkers as predictors of recovery in aphasia.
The adapted model list presented here is a first and useful step toward initiating a discussion of how neuroimaging biomarkers of recovery could be employed clinically to provide improved quality of care for individuals with aphasia.
旨在确定神经影像学生物标志物以预测失语症康复的研究文章数量持续增长。尽管已经提出了将这些生物标志物用于确定预后的临床应用，但对于如何实现这一目标的讨论却很少。这是一个重要的问题，因为当在研究过程的早期就考虑到转化时，就会产生最佳的转化科学。本临床重点文章的目的是提出一个框架，以指导讨论如何在临床上实施用于失语症康复的神经影像学生物标志物。
基因组学文献表明，在实际中实施基因检测既带来了机遇，也带来了挑战。这些机遇和挑战与那些与使用神经影像学测试来预测失语症康复相关的机遇和挑战有很多相似之处。因此，疾病控制中心旨在指导基因检测审查的问题模型列表已被改编，以指导使用神经影像学生物标志物作为失语症康复预测因子的讨论。
这里提出的经改编的模型列表是朝着讨论如何将神经影像学康复生物标志物临床应用以提高失语症患者护理质量迈出的第一步，也是一个有用的步骤。
