Cook Erin E, Gershman Susan T, Kim Jane J, Tamimi Rulla M, Klevens R Monina, Holmes Michelle D
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Massachusetts Cancer Registry, Massachusetts Department of Public Health, Boston, USA.
Cancer Causes Control. 2018 May;29(4-5):435-443. doi: 10.1007/s10552-018-1016-1. Epub 2018 Mar 1.
To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts.
From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U.S. population and trends were assessed using joinpoint regression.
While the incidence rate of cervical cancer (5.46 per 100,000) decreased by 2.41% annually (p = 0.004), the incidence rate of oropharyngeal cancer among males (7.85 per 100,000) increased by 2.82% annually (p = 0.0002). Mortality rates for both cancers decreased from 2008 to 2014 but were not statistically significant (cervical - 3.73% annually, p = 0.29; oropharyngeal - 1.94% annually, p = 0.44).
The rising incidence rate of oropharyngeal cancer in men and the decreasing, but relatively high, incidence rate of cervical cancer in women highlight the need for further screening and prevention by HPV vaccination in Massachusetts.
了解马萨诸塞州两种与人乳头瘤病毒（HPV）相关癌症——宫颈癌和口咽癌的发病率及死亡率趋势。
2004年至2014年期间，马萨诸塞州癌症登记处记录了3996例口咽癌发病病例和2193例宫颈癌发病病例。死亡率数据来自2008年至2014年马萨诸塞州生命统计登记处。发病率按2000年美国人口进行年龄标准化，并使用Joinpoint回归分析趋势。
宫颈癌发病率（每10万人中5.46例）每年下降2.41%（p = 0.004），而男性口咽癌发病率（每10万人中7.85例）每年上升2.82%（p = 0.0002）。两种癌症的死亡率在2008年至2014年期间均有所下降，但无统计学意义（宫颈癌每年下降3.73%，p = 0.29；口咽癌每年下降1.94%，p = 0.44）。
男性口咽癌发病率上升以及女性宫颈癌发病率虽下降但仍相对较高，这凸显了马萨诸塞州通过HPV疫苗接种进行进一步筛查和预防的必要性。
