Department of Biomedical Science and Technology, College of Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of Korea.
Exp Gerontol. 2018 Jun;106:39-45. doi: 10.1016/j.exger.2018.02.027. Epub 2018 Feb 27.
To investigate the relationship between involuntary weight loss with low muscle mass and health-related quality of life in a large representative sample of older adults.
A nationwide cross-sectional study based on data from the Korea National Health and Nutritional Examination Survey, 2008 to 2011. Study participants included 2249 individuals aged ≥70 years. The participants reported an unintentional weight loss >3 kg in the past year. Appendicular lean mass was measured using dual-energy X-ray absorptiometry and calculated with the appendicular lean mass index. Health-related quality of life was measured using the EuroQol-5 dimension (EQ-5D) instrument. Univariate and multivariate survey logistic regression models were used to calculate odds ratios (OR) with 95% confidence intervals (95% CI) for the lowest quintile of the EQ-5D index.
In total, 39.1% of participants were male and 60.9% were female. The weighted mean age was 75.6 years (95% CI; 75.3-75.9). Clinically significant weight loss is typically 5% of one's body weight; average, 2.8 kg (3.1 kg for men; 2.7 kg, women) for our participants. Compared with the normal reference group and after adjusting for potential confounders, the ORs for the lowest quintile of the EQ-5D indices were 1.39 (95% CI, 0.92-2.10), 2.56 (95% CI, 1.56-4.18), and 3.40 (95% CI, 2.05 to 5.63) for the low muscle mass, involuntary weight loss, involuntary weight loss with low muscle mass groups, respectively.
Involuntary weight loss combined with low muscle mass was more closely associated with poor quality of life than involuntary weight loss alone in community-dwelling older adults.
在一个大型的代表性老年人样本中，研究非自愿性体重下降伴低肌肉量与健康相关生活质量之间的关系。
这是一项基于 2008 至 2011 年韩国国家健康和营养检查调查数据的全国性横断面研究。研究对象包括 2249 名年龄≥70 岁的个体。参与者报告过去一年有非自愿性体重下降>3kg。四肢瘦体重使用双能 X 射线吸收法测量，并通过四肢瘦体重指数计算。使用欧洲五维健康量表（EQ-5D）仪器测量健康相关生活质量。使用单变量和多变量调查逻辑回归模型计算 EQ-5D 指数最低五分位数的比值比（OR）及其 95%置信区间（95%CI）。
共有 39.1%的参与者为男性，60.9%为女性。加权平均年龄为 75.6 岁（95%CI；75.3-75.9）。临床上显著的体重下降通常为体重的 5%；我们的参与者平均为 2.8kg（男性为 3.1kg；女性为 2.7kg）。与正常参考组相比，并在调整了潜在混杂因素后，EQ-5D 指数最低五分位数的 OR 分别为 1.39（95%CI，0.92-2.10）、2.56（95%CI，1.56-4.18）和 3.40（95%CI，2.05-5.63），分别为低肌肉量、非自愿性体重下降和非自愿性体重下降伴低肌肉量组。
与单纯非自愿性体重下降相比，社区居住的老年人中非自愿性体重下降伴低肌肉量与较差的生活质量更为密切相关。
