唐氏综合征成人进行 12 周运动干预后的认知功能变化。
Changes in cognitive function after a 12-week exercise intervention in adults with Down syndrome.
机构信息
Cardiovascular Research Institute, Division of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Cancer Prevention Fellowship Program, Division of Cancer Prevention, Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.
出版信息
Disabil Health J. 2018 Jul;11(3):486-490. doi: 10.1016/j.dhjo.2018.02.003. Epub 2018 Feb 26.
BACKGROUND
Between 250,000 and 400,000 individuals in the United States are diagnosed with Down syndrome (DS). Nearly all adults with DS will develop Alzheimer's disease pathology starting in their thirties. Recent studies suggest that increased physical activity (PA) may be important for maintaining components of cognition, including memory.
OBJECTIVE
The purpose of this study was to evaluate changes in cognitive function after completion of a 12-week exercise intervention in adults with DS.
METHODS
Participants were randomized to attend 30-minute group exercise sessions 1 or 2 times a week for 12 weeks. The exercise sessions were delivered via video conferencing on a tablet computer to groups of 5-8 participants. Sessions consisted of aerobic based exercises such as walking and jogging to music, dancing, as well as strength based exercises such as vertical jumps, bicep curls, and squats. Cognitive function was measured at baseline and end of study using the Cantab Dementia Battery for iPads, which assessed the cognitive domains of memory, attention, and reaction time.
RESULTS
Twenty-seven participants (27.9 ± 7.1 years of age, 40.7% female) enrolled and completed the 12-week intervention. Participants randomized to 1 session/week averaged 26.6 ± 3.0 min/week of PA from the group exercise session. Participants randomized to 2 sessions/week averaged 57.7 ± 15.3 min/week of PA from the group exercise sessions. Participants improved their performance on the two memory variables (p = 0.048 and p = 0.069).
CONCLUSION
Increased exercise may have positive changes on memory and other cognitive functions.
背景
在美国，有 25 万至 40 万人被诊断患有唐氏综合征（DS）。几乎所有患有 DS 的成年人都会在三十多岁时开始出现阿尔茨海默病的病理变化。最近的研究表明，增加身体活动（PA）可能对维持认知的各个组成部分，包括记忆力，非常重要。
目的
本研究旨在评估唐氏综合征成人完成 12 周运动干预后认知功能的变化。
方法
参与者被随机分配参加每周 1 或 2 次 30 分钟的小组运动，持续 12 周。运动课程通过平板电脑上的视频会议提供给每组 5-8 名参与者。课程包括有氧运动，如跟着音乐走和慢跑、跳舞，以及力量训练，如垂直跳跃、二头肌卷曲和深蹲。使用 Cantab 平板电脑痴呆症电池在基线和研究结束时测量认知功能，该电池评估了记忆、注意力和反应时间等认知领域。
结果
共有 27 名参与者（27.9±7.1 岁，40.7%为女性）入组并完成了 12 周的干预。每周参加 1 次小组运动的参与者平均每周从小组运动中获得 26.6±3.0 分钟的身体活动。每周参加 2 次小组运动的参与者平均每周从小组运动中获得 57.7±15.3 分钟的身体活动。参与者在两个记忆变量上的表现有所提高（p=0.048 和 p=0.069）。
结论
增加运动可能对记忆和其他认知功能产生积极的变化。
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