Çağlar Gamze Sinem, Garrido Nicolas
Department of Obstetrics and Gynecology, Ufuk University School of Medicine, Ankara, Turkey.
Andrology Laboratory and Sperm Bank at the Instituto Valenciano de Infertilidad, Valencia, Spain.
J Turk Ger Gynecol Assoc. 2018 Mar 1;19(1):48-52. doi: 10.4274/jtgga.2017.0031.
Human papilloma virus (HPV) is one of the most common viral sexually-transmitted diseases worldwide. The prevalence of HPV is higher in infertile males when compared with fertile men and ranges between 10 and 35.7% in men affected by unexplained infertility. HPV can bind to spermatozoa and can potentially be transferred to fertilized oocytes. Viral detection in blastocysts and trophoblastic cells is associated with impaired embryo development and poor pregnancy outcomes. Nevertheless, attempts to eliminate HPV-DNA from sperm samples through routine washing techniques have failed. In assisted reproduction technologies (ART), intracytoplasmic sperm injection involves no natural selection of the sperm cell, which means that these procedures have a plausible risk of injecting sperm containing HPV. The possible detrimental effects of HPV on ART in couples with infected male partners are summarized in this review.
人乳头瘤病毒（HPV）是全球最常见的病毒性传播疾病之一。与可育男性相比，不育男性中HPV的患病率更高，在患有不明原因不育症的男性中，HPV患病率在10%至35.7%之间。HPV可与精子结合，并有可能转移至受精卵。在囊胚和滋养层细胞中检测到病毒与胚胎发育受损和不良妊娠结局有关。然而，通过常规洗涤技术从精子样本中清除HPV-DNA的尝试均告失败。在辅助生殖技术（ART）中，胞浆内单精子注射不涉及精子细胞的自然选择，这意味着这些操作存在注射含有HPV精子的合理风险。本文综述了HPV对男性伴侣感染的夫妇辅助生殖技术可能产生的有害影响。
