Aver'yanov A V, Konoplyannikov A G, Antonov N S, Osipova G L, Vasil'eva O S, Sakharova M G, Tatarskii A R, Kobylyansky V I
Research Institute of Pulmonology, Federal Biomedical Agency, Moscow, Russia.
National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
Bull Exp Biol Med. 2018 Mar;164(4):576-578. doi: 10.1007/s10517-018-4034-9. Epub 2018 Mar 5.
We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (20%). After mesh nebulization, no live cells were found. Thus, compressor nebulization is the most preferable method of the production of cell aerosol for their delivery to the lower respiratory tract.
我们比较了细胞悬液经压缩雾化、超声雾化和网式雾化10分钟后骨髓间充质干细胞的存活率。经压缩雾化后，基质细胞的活力保存最佳（72%）。超声雾化后的细胞存活率显著降低（20%）。网式雾化后未发现活细胞。因此，压缩雾化是制备用于输送至下呼吸道的细胞气雾剂的最优选方法。
