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利用碲化镉量子点追踪脂肪组织移植物

tracking of adipose tissue grafts with cadmium-telluride quantum dots.

作者信息

Deglmann Claus J, Błażków-Schmalzbauer Katarzyna, Moorkamp Sarah, Wallmichrath Jens, Giunta Riccardo E, Rogach Andrey L, Wagner Ernst, Baumeister Ruediger G, Ogris Manfred

机构信息

Centre for Hand Surgery, Microsurgery and Plastic Surgery, Schoen-Klinik Muenchen Harlaching, Munich, Germany.

Department of Hand-, Plastic- and Aesthetic Surgery, Klinikum Grosshadern, LMU Munich, Munich, Germany.

出版信息

Arch Plast Surg. 2018 Mar;45(2):111-117. doi: 10.5999/aps.2017.01487. Epub 2018 Mar 5.

DOI:10.5999/aps.2017.01487
PMID:29506330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5869436/
Abstract

BACKGROUND

Fat grafting, or lipofilling, represent frequent clinically used entities. The fate of these transplants is still not predictable, whereas only few animal models are available for further research. Quantum dots (QDs) are semiconductor nanocrystals which can be conveniently tracked due to photoluminescence.

METHODS

Fat grafts in cluster form were labeled with cadmium-telluride (CdTe)-QD 770 and transplanted subcutaneously in a murine model. Photoluminescence levels were serially followed .

RESULTS

Tracing of fat grafts was possible for 50 days with CdTe-QD 770. The remaining photoluminescence was 4.9%±2.5% for the QDs marked fat grafts after 30 days and 4.2%± 1.7% after 50 days. There was no significant correlation in the relative course of the tracking signal, when vital fat transplants were compared to non-vital graft controls.

CONCLUSIONS

For the first-time fat grafts were tracked with CdTe-QDs. CdTe-QDs could offer a new option for tracking of fat grafts for at least 50 days, but do not document vitality of the grafts.

摘要

背景

脂肪移植，即脂肪填充，是临床常用的方法。这些移植组织的命运仍然不可预测，而可用于进一步研究的动物模型很少。量子点（QDs）是半导体纳米晶体，因其光致发光特性可方便地进行追踪。

方法

将簇状脂肪移植物用碲化镉（CdTe）-QD 770标记，并皮下移植到小鼠模型中。连续跟踪光致发光水平。

结果

使用CdTe-QD 770可对脂肪移植物进行50天的追踪。标记量子点的脂肪移植物在30天后剩余光致发光为4.9%±2.5%，50天后为4.2%±1.7%。将存活脂肪移植与非存活移植物对照相比，追踪信号的相对过程相对过程中无显著相关性。

结论

首次使用CdTe-QDs对脂肪移植物进行追踪。CdTe-QDs可为脂肪移植物追踪提供至少50天的新选择，但无法证明移植物的活力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/d56351295bf8/aps-2017-01487f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/36805f9d6320/aps-2017-01487f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/5702b59923ac/aps-2017-01487f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/3a499dda37d9/aps-2017-01487f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/d56351295bf8/aps-2017-01487f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/36805f9d6320/aps-2017-01487f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/5702b59923ac/aps-2017-01487f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/3a499dda37d9/aps-2017-01487f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4340/5869436/d56351295bf8/aps-2017-01487f5.jpg

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本文引用的文献

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Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation.无机纳米颗粒暴露：进入途径、免疫反应、生物分布及体外/体内毒性评估
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Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts.
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