氯噻酮而非氢氯噻嗪才是用于对照的正确利尿剂。
Chlorthalidone, not hydrochlorothiazide, is the right diuretic for comparison.
作者信息
Mehta Ravi Tejraj, Pareek Anil, Purkait Indranil
机构信息
Ipca Laboratories Limited, Mumbai, India.
出版信息
Clin Hypertens. 2018 Mar 1;24:4. doi: 10.1186/s40885-018-0089-1. eCollection 2018.
Abstract
We have read the study design "Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial" by Oh GC, et al. with interest. The authors aim to compare the efficacy of amlodipine or hydrochlorothiazide (HCTZ) with an ARB. However, we wish to highlight that chlorthalidone (CTD) is the evidence-based and recommended anti-hypertensive diuretic, and should replace HCTZ in the trial to effectively compare efficacy against the CCB amlodipine.
摘要
我们饶有兴趣地阅读了Oh GC等人的研究设计“钙通道阻滞剂与利尿剂联合血管紧张素II受体阻滞剂对高血压患者24小时中心血压和血管血流动力学参数的影响比较：一项多中心、双盲、活性对照、4期随机试验的研究设计”。作者旨在比较氨氯地平或氢氯噻嗪（HCTZ）与血管紧张素II受体阻滞剂（ARB）的疗效。然而，我们想强调的是，氯噻酮（CTD）是循证推荐的抗高血压利尿剂，应在试验中取代HCTZ，以便有效地比较与钙通道阻滞剂氨氯地平的疗效。
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