美洲心脏病学会（IASC）立场声明：氯噻酮与噻嗪类利尿剂的比较
Interamerican Society of Cardiology (IASC) position statement: Chlorthalidone vs. thiazide- diuretics.
作者信息
Pareek Anil, Messerli Franz H, Saravia Gustavo, Mehta Ravi Tejraj
机构信息
Medical Affairs & Clinical Research, Ipca Laboratories Limited, Mumbai, India.
Department of Cardiology, Mount Sinai Health Medical Center, Icahn School of Medicine, New York, USA.
出版信息
Int J Cardiol Hypertens. 2020 Sep 19;7:100054. doi: 10.1016/j.ijchy.2020.100054. eCollection 2020 Dec.
The Interamerican Society of Cardiology (IASC) Position Statement for hypertension management in Latin America is a practical and useful review of five different hypertension guidelines. Though, thiazide diuretics have been recommended as firstline option, the position statement needs to highlight differences the thiazide class. Chlorthalidone is structurally and pharmacokinetically distinct from thiazide- iuretics like hydrochlorothiazide with a longer half-life and 24-h anti-hypertensive effect. It has been shown to reduce cardiovascular morbidity and mortality in several landmark studies evaluating anti-hypertensives.
美洲心脏病学会（IASC）关于拉丁美洲高血压管理的立场声明是对五项不同高血压指南的实用且有益的综述。尽管噻嗪类利尿剂已被推荐为一线选择，但该立场声明需要突出噻嗪类药物之间的差异。氯噻酮在结构和药代动力学上与氢氯噻嗪等噻嗪类利尿剂不同，其半衰期更长，具有24小时的降压作用。在几项评估抗高血压药物的里程碑式研究中，已证明它能降低心血管发病率和死亡率。
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