Awad Nasser K, Niu Haitao, Ali Usman, Morsi Yosry S, Lin Tong
Biomechanics and Tissue Engineering Group, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia.
Membranes (Basel). 2018 Mar 6;8(1):15. doi: 10.3390/membranes8010015.
Small-diameter blood vessels (SDBVs) are still a challenging task to prepare due to the occurrence of thrombosis formation, intimal hyperplasia, and aneurysmal dilation. Electrospinning technique, as a promising tissue engineering approach, can fabricate polymer fibrous scaffolds that satisfy requirements on the construction of extracellular matrix (ECM) of native blood vessel and promote the adhesion, proliferation, and growth of cells. In this review, we summarize the polymers that are deployed for the fabrication of SDBVs and classify them into three categories, synthetic polymers, natural polymers, and hybrid polymers. Furthermore, the biomechanical properties and the biological activities of the electrospun SBVs including anti-thrombogenic ability and cell response are discussed. Polymer blends seem to be a strategic way to fabricate SDBVs because it combines both suitable biomechanical properties coming from synthetic polymers and favorable sites to cell attachment coming from natural polymers.
由于会出现血栓形成、内膜增生和动脉瘤扩张等情况，制备小直径血管（SDBVs）仍然是一项具有挑战性的任务。静电纺丝技术作为一种很有前景的组织工程方法，能够制造出满足天然血管细胞外基质（ECM）构建要求并促进细胞黏附、增殖和生长的聚合物纤维支架。在这篇综述中，我们总结了用于制造小直径血管的聚合物，并将它们分为三类：合成聚合物、天然聚合物和杂化聚合物。此外，还讨论了静电纺丝小直径血管的生物力学性能和生物活性，包括抗血栓形成能力和细胞反应。聚合物共混物似乎是制造小直径血管的一种策略性方法，因为它兼具合成聚合物所具有的合适生物力学性能以及天然聚合物所具有的有利于细胞附着的位点。
