Two New Anisic Acid Derivatives from Endophytic Fungus Rhizopycnis vagum Nitaf22 and Their Antibacterial Activity.

Rhizopycnis acids A () and B (), two new anisic acid derivatives, were obtained from the ethyl acetate extract of the fermentation cultures of , an endophytic fungus isolated from the healthy tissues of . The structures of the two compounds were determined through a series of 1D and 2D NMR and HRMS spectral analyses. Both compounds were the first anisic acid derivatives containing methylbutanoic/methylbutenoic acid group found in fungi. and displayed antibacterial activity against six tested bacteria with IC values in the range 16.1~81.3 μg/mL.