Zhang Xiyue, Liu Hui, Li Ling, Huang Cuishan, Meng Xiangbo, Liu Junzuo, Bai Xueling, Ren Ling, Wang Xinluan, Yang Ke, Qin Ling
Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, PR China.
Translational Medicine Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.
Regen Biomater. 2022 Feb 24;9:rbac011. doi: 10.1093/rb/rbac011. eCollection 2022.
Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture. However, the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to loosening. Thus, a new class of Cu-alloyed titanium (TiCu) alloys with excellent mechanical properties and bio-functionalization has been developed. In this study, the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of TiCu. The results showed that after implantation for 4 weeks, TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor expression. After 8 weeks, it could further promote the proliferation and differentiation of osteoblasts, mineralization and deposition of collagens, and then significantly increasing bone mineral density around the implant. In conclusion, TiCu alloy would enhance the fixation stability, accelerate the osteointegration, and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis environment. This study was the first to report the role and mechanism of a Cu-alloyed metal in promoting osteointegration in osteoporosis environment, which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys.
骨质疏松症是一种常见的骨骼疾病，使患者易于发生骨质疏松性骨折。然而，由钛及其合金制成的临床植入物骨整合性较差，愈合时间长且容易松动。因此，已开发出一类具有优异机械性能和生物功能化的新型铜合金钛（TiCu）合金。在本研究中，使用骨质疏松模型大鼠来研究TiCu的骨整合效果及其潜在机制。结果表明，植入4周后，TiCu合金可通过上调血管内皮生长因子表达促进植入物周围血管网络的重建。8周后，它可进一步促进成骨细胞的增殖和分化、胶原蛋白的矿化和沉积，进而显著提高植入物周围的骨密度。总之，TiCu合金将增强固定稳定性，加速骨整合，从而降低在骨质疏松环境中长期植入期间无菌性松动的风险。本研究首次报道了铜合金金属在促进骨质疏松环境中骨整合的作用和机制，为改善铜合金抗菌钛合金未来临床应用提供了新的有吸引力的支持。
