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个体化患者档案:弗拉默综合征表型的临床效用以及预测、预防和个性化医学的一般经验教训。

Individualised patient profile: clinical utility of Flammer syndrome phenotype and general lessons for predictive, preventive and personalised medicine.

作者信息

Golubnitschaja Olga, Flammer Josef

机构信息

1Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany.

2Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

出版信息

EPMA J. 2018 Feb 22;9(1):15-20. doi: 10.1007/s13167-018-0127-9. eCollection 2018 Mar.

Abstract

This case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation of the individualised patient profile. The authors emphasise the great clinical relevance of the FS and field-related research.

摘要

本病例报告介绍了一名女性患者,自青少年时期起,她显然患有弗拉默综合征(FS),这是一种明确界定的亚健康状况。此外,该患者还出现了一些并发病理状况,这些状况主要可能与家族(遗传)易感性有关,但其发展可能会受到FS表型的协同促进。对这些事实进行了深入分析,并提出了相应的假设,这些假设表明需要基于对个体化患者资料的准确解读,开展非常必要的预测性诊断和针对性预防措施。作者强调了FS及其相关领域研究的重大临床意义。

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