Diop Moustapha, Cisse-Diallo Viviane Marie Pierre, Ka Daye, Lakhe Ndèye Aissatou, Diallo-Mbaye Khardiata, Massaly Aminata, Dièye Alassane, Fall Ndèye Maguette, Badiane Aboubacar Sadikh, Thioub Daouda, Fortes-Déguénonvo Louise, Lo Gora, Diop Cheikh Tacko, Ndour Cheikh Tidiane, Soumaré Masserigne, Seydi Moussa
Service des Maladies Infectieuses et Tropicales, CHNU de Fann, Dakar, Sénégal.
Centre Médical Inter Armée Sud, Dakar, Sénégal.
Pan Afr Med J. 2017 Oct 10;28:127. doi: 10.11604/pamj.2017.28.127.13640. eCollection 2017.
Occult Hepatitis B corresponds to the presence of hepatitis B virus-deoxyribonucleic acid (HBV-DNA) in serum and/or in liver of a patient despite HBsAg negativity. Clinically, it is usually asymptomatic. Its reactivation is rare and commonly occurs in immunosuppressed individuals. We report the case of a 21-year old patient from Senegal, with homozygous sickle cell disease, presenting with cholestatic jaundice. Laboratory tests showed reactivation of occult Hepatitis B. This study emphasizes the need to systematically investigate the presence of occult Hepatitis B in patients with sickle cell disease suffering from acute liver disease.
隐匿性乙型肝炎是指尽管患者血清和/或肝脏中乙肝表面抗原（HBsAg）呈阴性，但仍存在乙肝病毒脱氧核糖核酸（HBV-DNA）。临床上，它通常无症状。其再激活很少见，常见于免疫抑制个体。我们报告了一例来自塞内加尔的21岁纯合子镰状细胞病患者，该患者出现胆汁淤积性黄疸。实验室检查显示隐匿性乙型肝炎再激活。本研究强调，对于患有急性肝病的镰状细胞病患者，有必要系统地调查隐匿性乙型肝炎的存在情况。
