Sports and Health Research Center, Tongji University Department of Physical Education, Shanghai 200092, China.
Tongji University School of Medicine, Shanghai 200092, China.
BMB Rep. 2018 Apr;51(4):200-205. doi: 10.5483/bmbrep.2018.51.4.236.
Exercise and resveratrol supplementation exhibit anti-obesity functions in the long term but have not been fully investigated yet in terms of their early potential effectiveness. Mice fed with high-fat diet were categorized into control (Cont), exercise (Ex), resveratrol supplementation (Res), and exercise combined with resveratrol supplementation (Ex ＋ Res) groups. In the four-week period of weight loss, exercise combined with resveratrol supplementation exerted no additional effects on body weight loss but significantly improved whole-body glucose and lipid homeostasis. The combined treatment significantly decreased intrahepatic lipid content but did not affect intramyocellular lipid content. Moreover, the treatment significantly increased the contents of mtDNA and cytochrome c, the expression levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha and its downstream transcription factors, and the activities of ATPase and citrate synthase. However, exercise, resveratrol, and their combination did not promote myofiber specification toward slow-twitch type. The effects of exercise combined with resveratrol supplementation on weight loss could be partly due to enhanced mitochondrial biogenesis and not to fiber-type shift in skeletal muscle tissues. [BMB Reports 2018; 51(4): 200-205].
运动和白藜芦醇补充剂在长期内表现出抗肥胖功能，但它们在早期潜在效果方面尚未得到充分研究。用高脂肪饮食喂养的小鼠分为对照组（Cont）、运动组（Ex）、白藜芦醇补充组（Res）和运动联合白藜芦醇补充组（Ex ＋ Res）。在为期四周的减肥期间，运动联合白藜芦醇补充对体重减轻没有额外作用，但显著改善了全身葡萄糖和脂质稳态。联合治疗显著降低了肝内脂质含量，但不影响肌内脂质含量。此外，该治疗显著增加了 mtDNA 和细胞色素 c 的含量、过氧化物酶体增殖物激活受体 γ 共激活因子 1α 及其下游转录因子的表达水平以及 ATP 酶和柠檬酸合酶的活性。然而，运动、白藜芦醇及其组合并没有促进肌纤维向慢肌纤维类型的特异性分化。运动联合白藜芦醇补充对体重减轻的影响部分可能是由于增强了线粒体生物发生，而不是骨骼肌组织中的纤维类型转变。[BMB 报告 2018；51(4): 200-205]。
