Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Korea.
BMB Rep. 2023 Jun;56(6):353-358. doi: 10.5483/BMBRep.2023-0040.
In the present study, to determine the efficacy of oral supplementation of ginseng berry extracts in augmenting exercise performance and exercise-associated metabolism, male mice were given orally 200 and 400 mg/kg of body weight (BW) of GBC for nine weeks. Although there are no differences in pre-exercise blood lactate levels among (1) the control group that received neither exercise nor GBC, (2) the group that performed only twice-weekly endurance exercise, and (3) and (4) the groups that combined twice-weekly endurance exercise with either 200 or 400 mg/kg GBC, statistically significant reductions in post-exercise blood lactate levels were observed in the groups that combined twice-weekly endurance exercise with oral administration of either 200 or 400 mg/kg GBC. Histological analysis showed no muscle hypertrophy, but transcriptome analysis revealed changes in gene sets related to lactate metabolism and mitochondrial function. GBC intake increased nicotinamide adenine dinucleotide levels in the gastrocnemius, possibly enhancing the mitochondrial electron transport system and lactate metabolism. Further molecular mechanisms are needed to confirm this hypothesis. [BMB Reports 2023; 56(6): 353-358].
在本研究中，为了确定人参浆果提取物口服补充对增强运动表现和运动相关代谢的功效，雄性小鼠连续 9 周每天口服 200 和 400mg/kg 体重（BW）的 GBC。虽然（1）未接受运动和 GBC 处理的对照组、（2）仅每周进行两次耐力运动的组以及（3）和（4）将每周两次耐力运动与 200 或 400mg/kg GBC 联合使用的组之间，运动前的血乳酸水平没有差异，但在将每周两次耐力运动与口服 200 或 400mg/kg GBC 联合使用的组中，运动后的血乳酸水平有显著降低。组织学分析显示肌肉没有肥大，但转录组分析显示与乳酸代谢和线粒体功能相关的基因集发生了变化。GBC 摄入增加了比目鱼肌中的烟酰胺腺嘌呤二核苷酸水平，可能增强了线粒体电子传递系统和乳酸代谢。需要进一步的分子机制来证实这一假设。[BMB 报告 2023;56(6):353-358]。
