From the Neuroradiology Unit (G.C.,G.P., F.T.)
Department of Clinical Sciences and Community Health (S.M., A.Z.), Laboratory of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro,".
AJNR Am J Neuroradiol. 2018 May;39(5):963-967. doi: 10.3174/ajnr.A5574. Epub 2018 Mar 8.
Evaluation of biometry is a fundamental step in prenatal brain MR imaging. While different studies have reported reference centiles for MR imaging biometric data of fetuses in the late second and third trimesters of gestation, no one has reported them in fetuses in the early second trimester. We report centiles of normal MR imaging linear biometric data of a large cohort of fetal brains within 24 weeks of gestation.
From the data bases of 2 referral centers of fetal medicine, accounting for 3850 examinations, we retrospectively collected 169 prenatal brain MR imaging examinations of singleton pregnancies, between 20 and 24 weeks of gestational age, with normal brain anatomy at MR imaging and normal postnatal neurologic development. To trace the reference centiles, we used the CG-LMS method.
Reference biometric centiles for the developing structures of the cerebrum, cerebellum, brain stem, and theca were obtained. The overall interassessor agreement was adequate for all measurements.
Reference biometric centiles of the brain structures in fetuses between 20 and 24 weeks of gestational age may be a reliable tool in assessing fetal brain development.
产前脑磁共振成像（MRI）中，体数据评估是基本步骤。虽然不同的研究已经报道了妊娠晚期 2 至 3 个孕期胎儿 MRI 体数据的参考百分位数，但没有人在妊娠中期 2 期内的胎儿中报告过。我们报告了妊娠 24 周内的大量胎儿脑的正常 MRI 线性体数据的百分位数。
我们从两家胎儿医学转诊中心的数据库中，对 3850 次检查进行了回顾性收集，纳入了 169 例单胎妊娠的产前脑 MRI 检查，这些胎儿在妊娠 20 至 24 周，具有正常的脑解剖结构和正常的产后神经发育。为了追踪参考百分位数，我们使用了 CG-LMS 方法。
获得了大脑、小脑、脑干和脑池的发育结构的参考体数据百分位数。所有测量的评估者之间的总体一致性是足够的。
妊娠 20 至 24 周胎儿脑结构的参考体数据百分位数可能是评估胎儿脑发育的可靠工具。
