缺氧、缺氧诱导因子-1α 和固有抗利什曼原虫免疫反应。
Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses.
机构信息
Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany.
出版信息
Front Immunol. 2018 Feb 22;9:216. doi: 10.3389/fimmu.2018.00216. eCollection 2018.
Abstract
Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in -infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.
摘要
低氧环境和缺氧诱导因子（HIFs）的积累是感染和炎症组织的特征。在这里，我们总结了目前关于感染组织中氧水平的知识，并讨论了哪些机制可能有助于利什曼病病变中的局部组织氧合。此外，我们还回顾了缺氧和 HIF-1 对先天抗利什曼免疫反应的作用。
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