Paajanen H, Brasch R C, Schmiedl U, Ogan M
Acta Radiol. 1987 Jan-Feb;28(1):79-83.
Chemical inflammation was induced subcutaneously in 10 rats using carrageenan mucopolysaccharide. Dual spin echo (SE) imaging of inflammatory loci was performed employing a 0.35 tesla resistive magnet. In addition, gadolinium-DTPA was administrated intravenously into 5 rats to evaluate the potential benefits of paramagnetic contrast medium for the detection and characterization of inflammatory loci. T2 weighted SE images demonstrated the edematous lesions as zones of high intensity. This was attributed to the increased relaxation times of lesions when compared to the adjacent soft tissue. The inflammation was also delineated on T1 weighted SE images, but only after injection of paramagnetic Gd-DTPA. Carrageenan mucopolysaccharide-induced lesions provide a useful experimental model for in vivo evaluation of soft tissue inflammation using magnetic resonance imaging. No special benefit of paramagnetic contrast enhancement was demonstrated in this model of local edema.
使用角叉菜胶多糖在10只大鼠皮下诱导化学性炎症。采用0.35特斯拉的电阻磁体对炎症部位进行双自旋回波（SE）成像。此外，对5只大鼠静脉注射钆-DTPA，以评估顺磁性造影剂在检测和表征炎症部位方面的潜在益处。T2加权SE图像显示水肿性病变为高强度区域。这归因于与相邻软组织相比，病变的弛豫时间增加。炎症在T1加权SE图像上也能显示，但仅在注射顺磁性钆-DTPA之后。角叉菜胶多糖诱导的病变为使用磁共振成像在体内评估软组织炎症提供了一个有用的实验模型。在这个局部水肿模型中，未显示出顺磁性对比增强的特殊益处。
