Health and Education Civil Association.
Fred Hutchinson Cancer Research Center, Seattle, Washington.
Am J Epidemiol. 2018 Aug 1;187(8):1577-1585. doi: 10.1093/aje/kwy030.
The Sabes Study evaluated a treatment-as-prevention intervention among cisgender men who have sex with men and transgender women in Lima, Peru-populations disproportionately affected by the human immunodeficiency virus (HIV) epidemic. The intervention was designed to prevent onward transmission of HIV by identifying HIV-negative high-risk individuals, testing them monthly for the presence of HIV, and then rapidly treating those who became HIV-positive. The main outcome of interest was the development of a model predicting the population-level impact of early detection of HIV infection and immediate initiation of antiretroviral therapy in this population. From July 2013 to September 2015, a total of 3,337 subjects were screened for HIV; 2,685 (80.5%) were negative, and 2,109 began monthly testing. We identified 256 individuals shortly after HIV acquisition, 216 of whom were enrolled in the treatment phase of the study. All participants were followed for 48 weeks (follow-up ended in 2017) and were then referred to the Peruvian Ministry of Health to continue receiving free HIV care and treatment. Initial findings from this intervention demonstrate that it is possible to recruit high-risk individuals, screen them for HIV, continue to test those who are initially HIV-negative in order to identify incident cases shortly after acquisition, and then rapidly link them to health care.
萨贝斯研究评估了在秘鲁利马针对与男性发生性行为的男性和跨性别女性的异性恋男性和跨性别女性进行的一项治疗即预防干预措施，这些人群受到人类免疫缺陷病毒（HIV）流行的不成比例的影响。该干预措施旨在通过识别 HIV 阴性的高危个体、每月对他们进行 HIV 检测并迅速治疗那些 HIV 阳性的个体，来防止 HIV 的传播。主要关注的结果是建立一个预测模型，预测在该人群中早期发现 HIV 感染并立即开始抗逆转录病毒治疗的人群水平影响。从 2013 年 7 月至 2015 年 9 月，共有 3337 人接受了 HIV 筛查；2685 人（80.5%）为阴性，2109 人开始每月接受检测。我们在 HIV 感染后不久发现了 256 名个体，其中 216 名被纳入研究的治疗阶段。所有参与者都随访了 48 周（随访于 2017 年结束），然后被转介到秘鲁卫生部继续接受免费的 HIV 护理和治疗。该干预措施的初步结果表明，招募高危个体、对其进行 HIV 筛查、继续对最初 HIV 阴性的个体进行检测以在感染后不久发现新病例，然后迅速将其与医疗保健联系起来是可行的。
