Carnuccio R, Di Rosa M, Guerrasio B, Iuvone T, Sautebin L
Br J Pharmacol. 1987 Mar;90(3):443-5. doi: 10.1111/j.1476-5381.1987.tb11193.x.
The preliminary characterization of ;vasocortin' a novel glucocorticoid-induced anti-inflammatory protein, is described. Vasocortin is released into the rat peritoneal cavity following systemic dexamethasone administration, has an apparent mol. wt. of 100 kD and inhibits rat dextran oedema. Vasocortin is distinct from lipocortin and is likely to be associated with the anti-inflammatory effect of glucocorticoids.
本文描述了一种新型糖皮质激素诱导的抗炎蛋白“血管皮质素”的初步特性。血管皮质素在全身给予地塞米松后释放到大鼠腹腔中,表观分子量为100kD,并能抑制大鼠右旋糖酐水肿。血管皮质素与脂皮质素不同,可能与糖皮质激素的抗炎作用有关。