Carnuccio R, Di Rosa M, Persico P
Br J Pharmacol. 1980 Jan;68(1):14-6. doi: 10.1111/j.1476-5381.1980.tb10691.x.
Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.
用氢化可的松(10微克/毫升)孵育的大鼠腹膜白细胞会释放一种抑制前列腺素生成的因子。这种类固醇诱导的抑制剂介导抗炎类固醇的抗磷脂酶作用,它可能是一种蛋白质或多肽,因为其形成会被放线菌酮(一种已知的蛋白质合成抑制剂)阻断。