氢化可的松诱导的大鼠白细胞中前列腺素生物合成抑制剂
Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.
作者信息
Carnuccio R, Di Rosa M, Persico P
出版信息
Br J Pharmacol. 1980 Jan;68(1):14-6. doi: 10.1111/j.1476-5381.1980.tb10691.x.
Abstract
Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.
摘要
用氢化可的松（10微克/毫升）孵育的大鼠腹膜白细胞会释放一种抑制前列腺素生成的因子。这种类固醇诱导的抑制剂介导抗炎类固醇的抗磷脂酶作用，它可能是一种蛋白质或多肽，因为其形成会被放线菌酮（一种已知的蛋白质合成抑制剂）阻断。
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Mechanism of action of glucocorticoids.糖皮质激素的作用机制。
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A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.多形核白细胞在吞噬过程中释放的前列腺素的趋化作用。
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Nature. 1979 Mar 29;278(5703):456-9. doi: 10.1038/278456a0.
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Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis.皮质类固醇对前列腺素生物合成的抑制作用需要RNA和蛋白质合成。
Nature. 1978 Jun 15;273(5663):552-4. doi: 10.1038/273552a0.
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