Department Chemistry and Chemical Processing Technology, Ulubey Vocational School, Laboratory Technology Program, Ordu, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University Trabzon, Turkey.
Int Braz J Urol. 2018 Jul-Aug;44(4):734-739. doi: 10.1590/S1677-5538.IBJU.2017.0404.
The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer.
In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected and serum FNDC5/ Irisin and carcinoembryonic antigen (CEA) levels were determined using enzyme-linked immunosorbent assay (ELISA).
FNDC5/irisin and CEA levels in renal cancer patients were significantly higher compared with the control group (p=0.0001, p=0.009, respectively). Also, FNDC5 levels was more sensitive and specific than CEA levels. The best cut-off points for FNDC5/ irisin were >105pg/mL and CEA were >2.67ng/mL for renal cancer.
FNDC5/Irisin may be used as a diagnostic biomarker for renal cancer.
本研究旨在确定血清纤维连接蛋白 III 型结构域蛋白 5（FNDC5）/鸢尾素在肾细胞癌患者中的诊断意义。
本研究共评估了 48 人。患者组包括 23 名经诊断患有肾肿瘤的患者，对照组为 25 名健康个体。经诊断患有肾肿瘤的患者接受了根治性或部分肾切除术的手术治疗。采集血液标本，使用酶联免疫吸附测定（ELISA）法测定血清 FNDC5/鸢尾素和癌胚抗原（CEA）水平。
与对照组相比，肾癌患者的 FNDC5/鸢尾素和 CEA 水平明显升高（p=0.0001，p=0.009）。此外，FNDC5 水平比 CEA 水平更敏感和特异。FNDC5/鸢尾素的最佳截断值>105pg/mL，CEA 的最佳截断值>2.67ng/mL，用于诊断肾癌。
FNDC5/鸢尾素可作为肾细胞癌的诊断生物标志物。
