Laboratory of Toxicology, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil.
Laboratory of Embryology and Developmental Biology, Department of Genetic and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil.
Reprod Toxicol. 2018 Apr;77:143-153. doi: 10.1016/j.reprotox.2018.03.002. Epub 2018 Mar 6.
Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed neuronal loss in hippocampal regions and in the raphe nuclei, and those from the 2X dose neuronal loss in CA1. Delayed intrauterine growth, induced embryo deaths and increased occurrence of foetal anomalies were observed at the 8X dose. At non-lethal doses, AYA enhanced embryolethality and the incidence of foetal soft-tissue and skeleton anomalies. This study suggested that AYA is developmentally toxic and that its daily use by pregnant women may pose risks for the conceptus.
大鼠在妊娠第 6-20 天经口给予叶卡（AYA），剂量相当于人类成人在宗教仪式中单次（1X）至 8 倍（8X）的平均剂量，妊娠结果在第 21 天评估。给予 4X 和 8X 剂量的大鼠在治疗期间死亡（44%和 52%），存活的大鼠出现肾脏损伤。8X 剂量组的大鼠在海马区和中缝核出现神经元丢失，2X 剂量组的大鼠在 CA1 区出现神经元丢失。在 8X 剂量组观察到宫内生长迟缓、胚胎死亡增加和胎儿畸形发生率增加。在非致死剂量下，AYA 增强胚胎致死率和胎儿软组织和骨骼畸形的发生率。本研究表明 AYA 具有发育毒性，孕妇每日使用可能对胎儿造成风险。
