Qi Ce, Sun Jin, Xia Yuan, Yu Renqiang, Wei Wei, Xiang Jingying, Jin Qingzhe, Xiao Hang, Wang Xingguo
Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology , Jiangnan University , Wuxi 214122 , Jiangsu , PR China.
Wuxi Maternity and Child Health Care Hospital , Wuxi 214000 , PR China.
J Agric Food Chem. 2018 Mar 28;66(12):3118-3126. doi: 10.1021/acs.jafc.8b01085. Epub 2018 Mar 15.
Fatty acid (FA) is the major energy resource in breast milk, which is important for infant development. FAs profiles with sn-2 positional preference were an important part of triacylglycerols due to their better availability. This profile is still not replicated in artificial formulas. This study quantified the FAs profile of total and sn-2 position in human breast milk samples from 103 healthy volunteers during colostrum, transitional, and mature stages. Multicomponent analysis showed significant differences in FAs profiles of different lactation periods, due to that with relative percentage less than 1%. Linoleic acid (LA), mostly located at the sn-1,3 positions of TAGs, was more common in the milk of Chinese women than in western women. The majority of the breast milk did not meet the standard for the ratio of LA/α-linolenic acid for infant formula. FAs related to brain development, mainly at sn-2 in TAGs, were enriched in colostrum. Capric and lauric acids were enriched in transitional and mature breast milk, and capric acid showed sn-1,3 selectivity in TAGs. This study will aid the development of infant formula containing TAGs more similar to human breast milk.
脂肪酸（FA）是母乳中的主要能量来源，对婴儿发育至关重要。具有sn-2位置偏好的脂肪酸谱是三酰甘油的重要组成部分，因为它们的可用性更高。这种谱在人工配方奶粉中仍未得到复制。本研究对103名健康志愿者在初乳期、过渡乳期和成熟乳期的母乳样本中总脂肪酸和sn-2位置的脂肪酸谱进行了定量分析。多组分分析显示，不同哺乳期的脂肪酸谱存在显著差异，差异相对百分比小于1%。亚油酸（LA）主要位于三酰甘油的sn-1,3位置，中国女性乳汁中的亚油酸比西方女性乳汁中的更常见。大多数母乳不符合婴儿配方奶粉中亚油酸/α-亚麻酸比例的标准。与大脑发育相关的脂肪酸主要位于三酰甘油的sn-2位置，在初乳中含量丰富。癸酸和月桂酸在过渡乳和成熟乳中含量丰富，癸酸在三酰甘油中表现出sn-1,3选择性。本研究将有助于开发含有更接近人乳三酰甘油的婴儿配方奶粉。
