Craven Lyndsey, Murphy Julie, Turnbull Doug M, Taylor Robert W, Gorman Grainne S, McFarland Robert
a Wellcome Centre for Mitochondrial Research, Institute of Neuroscience , Newcastle University , Newcastle upon Tyne , UK.
New Bioeth. 2018 Apr;24(1):57-73. doi: 10.1080/20502877.2018.1440725.
The development of any novel reproductive technology involving manipulation of human embryos is almost inevitably going to be controversial and evoke sincerely held, but diametrically opposing views. The plethora of scientific, ethical and legal issues that surround the clinical use of such techniques fuels this divergence of opinion. During the policy change that was required to allow the use of mitochondrial donation in the UK, many of these issues were intensely scrutinised by a variety of people and in multiple contexts. This extensive process resulted in the publication of several reports that informed the recommendations made to government. We have been intrinsically involved in the development of mitochondrial donation, from refining the basic technique for use in human embryos through to clinical service delivery, and have taken the opportunity in this article to offer our own perspective on the issues it raises.
任何涉及人类胚胎操作的新型生殖技术的发展几乎不可避免地会引发争议，并引发人们真诚秉持但却截然相反的观点。围绕此类技术临床应用的大量科学、伦理和法律问题加剧了这种意见分歧。在英国允许使用线粒体捐赠所需的政策变革过程中，许多此类问题在各种场合受到了不同人群的严格审视。这一广泛过程产生了几份报告，为向政府提出的建议提供了依据。我们从完善用于人类胚胎的基本技术一直到临床服务提供，都深度参与了线粒体捐赠的发展，并借此机会在本文中就其引发的问题发表我们自己的看法。
