Vasil'eva V I, Sumarokov A A, Kozhevnikova L K, Asratian A A, Gorbunov M A
Zh Mikrobiol Epidemiol Immunobiol. 1987 Feb(2):32-5.
The present communication deals with the results of investigations on the frequency of HBsAg-carriership among expectant mothers in Fergana (the Uzbek SSR) and on the risk for their children to be infected with hepatitis B virus. To detect the markers of hepatitis B virus, the passive hemagglutination test, the enzyme immunoassay, and the radioimmunoassay were used. The incidence rate of HBsAg-carriership among expectant mothers was rather high (5.1 +/- 0.52%) in comparison with the control group (3.5 +/- 0.70%). The detection of HBsAg in children 3 months after their birth, i.e. at the term corresponding to the possible incubation period of hepatitis B, suggested that the children were infected at birth. As noted in the course of this investigation, the risk for a newborn to be infected was directly related to the titer of HBsAg, as well as to the presence of HBeAg, in the blood of the carrier mother. A high detection rate of HBsAg was registered among children born to HBsAg-carrier mothers, which makes it possible to consider these children as a high risk group with respect to hepatitis B virus infection and necessitates the development of the system of antiepidemic and prophylactic measures for preventing newborns to be infected with hepatitis B.
本报告涉及对费尔干纳（乌兹别克苏维埃社会主义共和国）孕妇中乙肝表面抗原（HBsAg）携带率的调查结果，以及她们的孩子感染乙型肝炎病毒的风险。为检测乙型肝炎病毒标志物，采用了被动血凝试验、酶免疫测定法和放射免疫测定法。与对照组（3.5±0.70%）相比，孕妇中HBsAg携带率相当高（5.1±0.52%）。在孩子出生3个月后，即在相当于乙型肝炎可能潜伏期的时期检测到HBsAg，表明孩子在出生时就受到了感染。在本次调查过程中发现，新生儿受感染的风险与携带病毒母亲血液中HBsAg的滴度以及HBeAg的存在直接相关。在HBsAg携带母亲所生的孩子中，HBsAg的检出率很高，这使得可以将这些孩子视为感染乙型肝炎病毒的高危人群，并且有必要制定防疫和预防措施体系，以防止新生儿感染乙型肝炎。
