[苏联不同地区乙肝表面抗原携带者中的乙肝e抗原及其抗体]

[HBe antigen and its antibodies in HBsAg carriers in various regions of the USSR].

作者信息

Mikhaĭlov M I, Arakelov S A, Vorozhbieva T E, Zhavoronok S V, Zubov S V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1985 Jul(7):71-4.

Abstract

A total of 300 blood serum samples, containing HBsAg and obtained from donors in three regions of the USSR (the RSFSR, the Uzbek SSR and the Moldavian SSR) differing in the level of HBsAg carriership, were studied for the presence of HBeAg and antibodies to this antigen in the passive hemagglutination (PHA) test and in the enzyme immunoassay (EIA). The occurrence of HBeAg was found to depend on the level of HBsAg carriership in the region. Thus, according to the EIA results, in Gorky, Kishinev and Tashkent HBeAg was detected, respectively, in 5.5%, 12.3% and 13.3% of serum samples, the level of HBsAg carriership in these cities being, according to the results of the PHA test, 1.4%, 5.0% and 9.0%. As shown by the results of EIA, the occurrence of HBeAg increased with the rise of the titer of HBsAg, while regarding the occurrence of antibodies to HBeAg the reverse relationship was observed.

摘要

共研究了300份含有乙肝表面抗原（HBsAg）的血清样本，这些样本取自苏联三个地区（俄罗斯苏维埃联邦社会主义共和国、乌兹别克苏维埃社会主义共和国和摩尔达维亚苏维埃社会主义共和国）的献血者，这三个地区的乙肝表面抗原携带率不同。采用被动血凝试验（PHA）和酶免疫测定（EIA）检测这些样本中乙肝e抗原（HBeAg）的存在情况以及针对该抗原的抗体。结果发现，HBeAg的出现取决于该地区HBsAg的携带率。因此，根据EIA检测结果，在高尔基市、基希讷乌市和塔什干市，分别在5.5%、12.3%和13.3%的血清样本中检测到HBeAg，而根据PHA检测结果，这些城市的HBsAg携带率分别为1.4%、5.0%和9.0%。EIA检测结果表明，HBeAg的出现随着HBsAg滴度的升高而增加，而对于HBeAg抗体的出现情况，则观察到相反的关系。