Makedou Kali G, Vagdatli Eleni, Patziarela Evangelia, Konstantinidou Vasiliki, Poimenidou Eirini, Lymperaki Evgenia
Aristotle University of Thessaloniki, Faculty of Health Sciences, Laboratory of Biological Chemistry, Thessaloniki, Greece.
Alexandrion Technological Education Institute of Thessaloniki, Department of Medical Laboratory Studies, School of Health Care Professions, Thessaloniki, Greece.
Open Access Maced J Med Sci. 2018 Feb 14;6(2):284-286. doi: 10.3889/oamjms.2018.095. eCollection 2018 Feb 15.
Orthodox Christian believers fast abstaining from meat, eggs, dairy products or even fish and oil in certain days of the fasting period, three times a year.
The present study aimed to investigate the impact of a 48-day fast before Easter in blood count parameters, coagulation and antioxidant status.
A total of 35 healthy volunteers, 19-66 years old, were included in the study. White blood cells (WBC), lymphocytes (Lymph), granulocytes (Gran), haemoglobin (Hb), hematocrit (Ht), red blood cells (RBC), mean erythrocyte volume (MCV), platelets (Plt), were measured. Blood coagulation parameters, such as PT, aPTT, fibrinogen concentration, factor VII activity were also determined, and INR (PTsample/PTcontrol) and aPTT ratio (aPTTsample/aPTTcontrol) were calculated. Total antioxidant capacity (TAC) was assayed.
Levels of all parameters remained within normal. By the end of the fasting period, lymphocytes and TAC levels were significantly increased (p = 0.011), whereas all the other parameters, except fibrinogen, were significantly decreased.
Orthodox Christian fast impairs all haematological and coagulation parameters and seems to be beneficial in the body antioxidant protection.
东正教信徒一年三次在斋戒期的特定日子禁食肉类、蛋类、奶制品，甚至鱼类和油脂。
本研究旨在调查复活节前48天斋戒对血细胞计数参数、凝血和抗氧化状态的影响。
共纳入35名19至66岁的健康志愿者参与研究。检测白细胞（WBC）、淋巴细胞（Lymph）、粒细胞（Gran）、血红蛋白（Hb）、血细胞比容（Ht）、红细胞（RBC）、平均红细胞体积（MCV）、血小板（Plt）。还测定了凝血参数，如PT、活化部分凝血活酶时间（aPTT）、纤维蛋白原浓度、因子VII活性，并计算国际标准化比值（INR，PT样本/PT对照）和aPTT比值（aPTT样本/aPTT对照）。测定总抗氧化能力（TAC）。
所有参数水平均保持在正常范围内。在斋戒期结束时，淋巴细胞和TAC水平显著升高（p = 0.011），而除纤维蛋白原外的所有其他参数均显著降低。
东正教斋戒会损害所有血液学和凝血参数，但似乎对身体抗氧化保护有益。
